ChemDraw’s “Chemical Properties” window predicts LogP and CLogP for almost all substances. The “Chemical Properties” report window looks up empirical values for LogP and CLogP for selected substances. The same tools are available in Chem3D’s “Property Picker” and in ChemBioFinder.

How do you calculate LogP?

Why is LogP important in drug formulation?

LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the organic elution solvent like dichloromethane, ethyl acetate or MTBE.

What does LogP value indicate?

The Log P value of the compound indicates the permeability of the drugs to reach the target tissue in the body.

Can ChemDraw calculate LogP? – Related Questions

What is a good LogP value for a drug?

LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption.

What does a LogP of a drug mean?

Definition: A measure of the preference of a compound to dissolve in either water or an organic solvent (such as octanol) when uncharged. More technically, it is the logarithm of the partition coefficient (P) of a molecule between an aqueous and lipophilic phase.

How do you know if a drug is lipophilic?

Lipophilicity can be measured by the distribution of a drug between the organic phase, which is generally n-octanol pre-saturated with water, and the aqueous phase, which is generally water pre-saturated with n-octanol.

How does lipophilicity affect drug absorption?

As well as affecting the absorption and metabolism of a drug, lipophilicity also influences its binding and distribution. Generally, the higher the lipophilicity of a drug, the stronger its binding to protein and the greater its distribution.

How do you know if something is lipophilic?

A substance is lipophilic if it is able to dissolve much more easily in lipid (a class of oily organic compounds) than in water. More: The degree of lipophilicity is expressed as octanol-water partitioning coefficient: Kow.

Is lipophilic the same as hydrophobic?

However, the terms “lipophilic” and “hydrophobic” are not synonymous, as can be seen with silicones and fluorocarbons, which are hydrophobic but not lipophilic.

What LogP is lipophilic?

Lipophilicity, as the ability of a molecule to mix with an oily phase rather than with water, is usually measured as partition coefficient, P, between the two phases and is often expressed as log P. ⁴⁷.

What is an example of lipophilic?

Nimodipine has lipophilic properties and can easily cross the blood-brain barrier. The drug is highly lipophilic and able to cross the blood brain barrier at higher doses.

What are examples of lipophilic drugs?

How does LogP affect permeability?

(22) The parameter that determines the lipophilicity of a molecule is LogP (the partition coefficient of the molecule between an aqueous and lipophilic phase, usually water and octanol). LogP is a crucial factor governing passive membrane partitioning; an increase in LogP enhances permeability.

What is difference between hydrophilic and lipophilic?

The classification of drugs as hydrophilic or lipophilic depends on their ability to dissolve in water or in lipid-containing media. In this respect, absorption is faster in lipophilic drugs, whereas the ease for renal excretion is greater in hydrophilic medications.

Why Most drugs are lipophilic?

Lipophilicity of drug candidate molecules is a major concern in the development of its dosage form, because drug molecules must penetrate the lipid bilayer of most cellular membranes, including that of the enterocytes. Therefore, it is generally believed that drug molecules must be lipophilic to have good absorption.

What happens if drug is too lipophilic?

It is often observed that drugs that are in the early stages of development have high lipophilicity. This often leads to compounds that have a high rate of metabolism, leading to poor solubility, high turn-over, and low absorption. Very high levels of lipophilicity can also lead to toxicity and metabolic clearance.

What’s lipophilic mean?

Definition of lipophilic

: having an affinity for lipids (such as fats) a lipophilic metabolite.

Are lipophilic drugs better absorbed?

It is generally admitted in drug research that the passage of molecules across cellular barriers increases with lipophilicity and that the most lipophilic compounds will have the highest intestinal absorption.

What is a highly lipophilic drug?

Highly lipophilic drugs (Log P > 5, triglyceride solubility >50 mg per g) can be transported to the systemic circulation by the intestinal lymphatic system rather than the portal vein blood following oral delivery. This transport is mediated by association of the lipophilic drug with lymphatic lipids.